Prognostic evaluation of sex difference in adenosine deaminase and homocysteine activities of acute ischemic stroke patients

Amit R. Nayak, Rajpal S. Kashyap, Dinesh Kabra, Hemant J. Purohit, Girdhar M. Taori, Hatim F. Daginawala
412 275

Abstract


Abstract

Aim of the present study was to investigate serial changes in adenosine deaminase (ADA) and total homocysteine (tHcy) activities in male and female acute ischemic stroke (AIS) patients to determine their prognostic value. ADA and tHcy activities were measured in follow-up blood sample collected from AIS patients at admission, 24 hrs, 48 hrs, 72 hrs, and 144 hrs after admission and in control subjects. We did not observe any significant difference in ADA and tHcy activities between male and female of AIS and control subjects. ADA activity was significantly high in male AIS patients as compare to female throughout the follow-up. There were no significant difference in tHcy activity between male and female of AIS patients. Similarly there were no significant differences in ADA and tHcy activities on comparing follow-up samples of AIS patients with that of admission value. In addition, m-RS scale in female was better than male AIS patients. Findings of this preliminary study suggest that increase in ADA activity in male AIS patient may reflect poor outcome than female. The tHcy activity is not related with the severity and out come after AIS. Further prospective studies are needed to see if ADA is clinically useful in outcome prediction after AIS.

Keywords: Acute ischemic stroke, adenosine deaminase, homocysteine, prognosis

Özet

Bu araştırmanın amacı erkek ve kadın akut iskemik inme hastalarında adenozin deaminaz (ADA) ve total homosistein (tHcy) aktivitelerindeki seri değişimin prognostik değerlerini belirlemektir. ADA ve tHcy aktiviteleri kontrol bireylerden ve kabulde, kabulden 24, 48, 72 ve 144 saat sonra akut istemik inme hastalarından ölçüldü. Kontrol ve akut iskemik inme olgularında kadın ve erkek bireylerin ADA ve tHcy aktiviteleri benzer bulundu.  ADA aktivitesi erkek AIS hastalarında kadınlara göre belirgin şekilde yüksektir. Erkek ve kadın AIS hastalarında tHcy aktivitelerinde önemli bir fark yoktur. Benzer şekilde AIS hastalarının kabul ve takip ADA ve tHcy aktivitelerinde belirgin bir fark yoktur. Ayrıca kadın hastaların m-RS ölçüleri erkek AIS hastalarından daha iyidir. Bu öncül çalışmanın bulguları erkek AIS hastalarındaki ADA aktivitesinin artışı bayanlara göre daha önemsiz olmasıdır. tHcy aktivitesi AIS sonrası sonuç ve ölçüsü olamadığını gösterir. AIS sonrası tahminler için ADA'nın klinik olarak kullanılıp kullanılmayacağı için daha fazla prospektif çalışmaya ihtiyaç vardır.  

 Anahtar sözcükler: Akut istemik inme, adenozin deaminaz, homosistein, prognoz


Keywords


Acute ischemic stroke, adenosine deaminase, homocysteine, prognosis

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DOI: http://dx.doi.org/10.12808/bcs.v2i1.19

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Basic and Clinical Sciences

The Basic and Clinical Sciences is an international, peer-reviewed, open access, online journal. In the Journal, Original Articles, being the majority of published papers, Reviews, Short communications, Case reports, and Letters to the Editor are published. 

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