Novel metal complexes of mixed piperaquine-acetaminophen and piperaquine-acetylsalicylic acid: Synthesis, characterization and antimicrobial activities

Yusuf Oloruntoyin Ayipo, Joshua Ayoola Obaleye, Umar Muhammad Badeggi
1.740 218

Abstract


Synthesis of coordination compounds of Zinc(II), Copper(II), Nickel(II), Cobalt(II) and Iron(II) with mixed piperaquine-acetaminophen and piperaquine-acetylsalicylic acid has been studied. The complexes were characterized via: solubility test, melting point determination, conductivity measurement, Atomic Absorption Spectroscopy, UV-Visible Spectroscopy, FTIR Spectroscopy and magnetic susceptibility. The complexes were proposed to have a stoichiometry ratio of 1:1:1 between each metal salt and the ligands with tetrahedral and octahedral geometry following the reaction pattern of MX.yH2O + L1L2/3 to give ML1L2/3X.yH2O. Biological activities of the synthesized complexes have been evaluated against Escherichia coli and Staphylococcus aureus.


Keywords


Antimalaria, Analgesic, Mixed ligands, Metal complexes, Spectroscopy, Biological activities

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References


Wiesner J., Ortmann R., Jomaa H., and Schlitzer M., New Antimalarial Drugs, Angew. Chem. Internat. Ed. Engl., 2003, 42 (43) , 5274-5293.

Maribel N., Techniques used to Study MetalloDrugs-DNA interactions, Ivic Instituto Venezolano De Investigaciones Cientifica, 23-30 Julio, 2010.

World Health Organisation, Model Formulary for Children (2nd ed.), 2010, ISBN 978-92-4-159932-0. http://www.who.int/entity/selection_medicines/list/WMFc_2010.pdf. Retrieved 2011-03-30

World Health Organisation, Model List of Essential Medicines for Children (2nded.), 2010, http://www.who.int/entity/medicines/publications/essentialmedicines/Updated_second_children_list_en.pdf. Retrieved 2011-03-30.

Obaleye J. A., Amolegbe S. A. and Gbotoso G. O., Some metal-antimalarial drug complexes: synthesis, characterization and their effect against malaria parasites, http://www.journal.unaab.edu.ng/index.php/COLNAS/article/viewFile/193/190, 2006.

Olliaro P. L. and Taylor W. R., Antimalarial compounds: from bench to bedside. J Exp Biol, 2003, 206:3753-3759.

Marcus J. R., Rose M., Machteld E. B., Marion B., Stephane P., Mupawjay P., Pratap S. and Francois N., Dihydroartemisinin-Piperaquine Rescue Treatment of Multidrug-resistant Plasmodium Falciparum Malaria in Pregnanc. American Journal of Tropical Medicine and Hygiene, 2008, 78 (4) 543 – 545.

Sanjukta B. Ranbaxy Laboratory Ltd., India. www.synriam.com/2synriamRanbaxy.pdf, 2013.

Ogunniran K. O., Ajani O. O., Ehi-Eromosele C. O., Obaleye J. A., Adekoya J. A. and Ajanaku C. O., Cu(II) and Fe(III) complexes of sulphadoxine mixed with pyramethamine: synthesis, characterization, antimicrobial and toxicology study. International Journal of Physical Science, 2012, Vol. 7(13), pp 1998 – 2005.

Shruti S. S., Jadhav W. N., Khade B. C. and Arbad B. R., Synthesis, characterization and antimicrobial study of some 3d metal complexes of sulfadoxine. International Journal of ChemTech Research, 2014, Vol. 6, No 4, pp 2291 – 2294.

Cotton F. A., Geoffrey W. and Carlos A. M., Advanced Inorganic Chemistry, Wiley, New York, NY, 1988, 6th Ed. ISBN: 978-0-471-19957-1

Miessler G. L.; Donald A. T., Inorganic Chemistry, Pearson Education Inc., U. S. A., 1999, pp. 642. ISBN: 978-0321811059

Encyclopedia Britannica, https://en.wikipedia.org/wiki/Encyclopædia_Britannica, 2010.

Adediji J. F., Olayinka E. T., Adebayo M. A. and Babatunde O., Antimalarial mixed ligand metal complexes: Synthesis, physicochemical and biological activities. International Journal of Physical Sciences, 2009, 4 (9) 529 – 534.

Lee, J. D., Coincise Inorganic Chemistry; Wiley: India, 1999, pp 223 – 232.

Karunajeewa H., Lim C., Hung T. Y., Ilett K. F., Denis M. B., Socheat D. and Davis T. M., Safety evaluation of fixed combination piperaquine plus dihydroartemisinin (Artekin) in Cambodian children and adults with malaria. Br J Clin Pharmacol, 2004, 57:93-99.

Lawal A. and Obaleye J. A., Synthesis, characterization and antibacterial activity of aspirin and paracetamol-metal complexes. BIOKEMISTRY, 2006, 19 (1): 9-15.

Wikipedia: en.wikibooks.org/wiki/Inorganic_Chemistry/Qualitative_Analysis/Tests_for_anions




J. Turk. Chem. Soc., Sect. A: Chem.