Bazı İmidazol ve İmidazo[1,2-a] Pirazin Türevlerinin Antikanser Aktiviteleri Üzerine QSAR Çalışmaları

İsmail KAYAĞİL, Şeref DEMİRAYAK
1.305 445

Öz


Bu çalışmada, antikanser etkiler (Amerika Ulusal Kanser Enstitüsü (NCI) tarafından, 66 kanserli hücrede yapılmış olan büyüme testlerinden alınan Log(1/C) değerleri)  ile bazı fizikokimyasal parametreler (hidrofobik parametreler olarak clogP, p, elektronik parametreler olarak σ, Ŧ, ve sterik parametreler olarak, Es, MR) arasındaki korelasyonlar incelenmiştir. Buna göre, imidazol türevleri için, biyolojik etki ile p, Ŧ, MR parametreleri arasında ve benzer şekilde, imidazo[1,2-a]pirazin türevleri için, biyolojik etki ile clogP, Es parametreleri arasında önemli miktarda korelasyon olduğu rapor edilmiştir.

Anahtar Kelimeler: İmidazo[1,2-a]pirazin, pirazino[1,2-a]benzimidazol, antikanser etki, kantitatif yapı-etki ilişkileri (QSAR), Hansch analiz metodu


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