Synthesis and Antinociceptive Activity of 2-[(2-Oxobenzothiazolin-3-yl)methyl]- 5-aminoalkyl/aryl-1,3,4-thiadiazole
Ten 2-[(2-oxobenzothiazolin-3-yl)methyl]-5-aminoalkyl/aryl-1,3,4-thiadiazole derivatives were synthesized. The chemical structures of these compounds were elucidated by their FT-IR and 1H-NMR spectral data, as well as their elemental analyses. The compounds were tested for antinociceptive activity. Among these compounds, 2-[(2-oxobenzothiazolin-3-yl)methyl]-5-aminomethyl-1,3,4-thiadiazole (5a) was found to be significantly more active than the others and the standards in all the tests.
2-Oxobenzothiazoline, 1,3,4-thiadiazole, antinociceptive activity