Evaluation of hepatocellular carcinoma with computed tomography perfusion imaging

Ümmügülsüm BAYRAKTUTAN, Abdulmecit KANTARCI, Hayri OĞUL, Yeşim KIZRAK, Ömer ÖZYİĞİT, Zeyneb YÜCELER, Berhan GENÇ, Bünyami ÖZOĞUL
425 125


To evaluate the role of computed tomography (CT) perfusion imaging in patients with hepatocellular carcinoma (HCC). Materials and methods: Seventeen patients (9 men, 8 women) with newly diagnosed HCC, proven by biopsy, were evaluated with 256-slice helical CT. Perfusion parameters of blood flow (BF), blood volume (BV), arterial perfusion (AP), portal perfusion (PP), and hepatic perfusion index (HPI) were calculated in the normal liver parenchyma and HCC samples. Results: A total of 21 histologically proven HCC lesions were evaluated from CT perfusion images. BF, BV, AP, and HPI values were shown to be significantly higher (P < 0.05) in the HCC lesions than in the normal liver parenchyma. Conversely, PP values were found to be significantly lower (P < 0.05) in HCC relative to liver parenchyma. Conclusion: CT perfusion imaging has the ability to evaluate tumor assessment, characterization, and neoangiogenesis in HCC.


Key words: Computed tomography, perfusion imaging, hepatocellular carcinoma

Full Text:



Palma LD. Diagnostic imaging and interventional therapy of hepatocellular carcinoma. Br J Radiol 1998; 71: 808–18. Wong R, Frenette C. Updates in the management of hepatocellular carcinoma. Gastroenterol Hepatol 2011; 7: 16–24.

Yang L, Zhang XM, Tan BX, Liu M, Dong GL, Zhai ZH. Computed tomographic perfusion imaging for the therapeutic response of chemoembolization for hepatocellular carcinoma. J Comput Assist Tomogr 2012; 36: 226–30.

Koşar PN, Koçak Tufan Z, Ergün E, Yiğit H, Koşar U, Demiröz AP. Chest radiography and computed tomography findings of cases with pandemic influenza A (H1N1/09) infection. Turk J Med Sci 2012; 42: 787–95.

Miles KA. Perfusion CT for the assessment of tumor vascularity: which protocol? Br J Radiol 2003; 76: 36–42. Miles KA, Hayball MP, Dixon AK. Functional images of hepatic perfusion obtained with dynamic CT. Radiology 1993; 188: 405–11.

Zhu AX, Holalkere NS, Muzikansky A, Horgan K, Sahani DV. Early antiangiogenic activity of bevacizumab evaluated by computed tomography perfusion scan in patients with advanced hepatocellular carcinoma. Oncologist 2008; 13: 120–5.